A two+ hour drive would really take it out of me. I would often have to stop and have a 10 minute nap.
I’ve found meds have really helped, I still feel tired, but I don’t have to sleep afterwards or take naps.
Same with riding motorbike, but double. I think it’s the intense concentration for long periods of time.
I started taking medication before I started driving so I can’t speak from experience regarding that, but I do find when I drive I concentrate a ton so when I finish driving I get really tired.
I don’t like driving much so I try to cycle and take public transit whenever possible.