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Joined 9 months ago
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Cake day: September 28th, 2023

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  • Very interesting research!

    SUMMARY

    Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited. In this study, we demonstrate that NIC increases the abundance and proliferative activity of intestinal stem cells (ISCs) in vivo and ex vivo. Moreover, NIC induces Yes-associated protein (YAP)/Transcriptional coactivator with PDZ-binding motif (TAZ) and Notch signaling in ISCs via α7-nicotinic acetylcholine receptor (nAchR) and protein kinase C (PKC) activation; this effect was not detected in Paneth cells. The inhibition of Notch signaling by dibenzazepine (DBZ) nullified the effects of NIC on ISCs. NIC enhances in vivo tumor formation from ISCs after loss of the tumor suppressor gene Apc, DBZ inhibited NIC-induced tumor growth. Hence, this study identifies a NIC-triggered pathway regulating the stemness and tumorigenicity of ISCs and suggests the use of DBZ as a potential therapeutic strategy for treating intestinal tumors.

    https://www.biorxiv.org/content/10.1101/2024.01.02.573853v1





  • Lazy Chicken

    1. Pour about a centimeter white rice in a baking dish. I prefer something a 20x30cm tempered glass one, but I’m sure you can use whatever.
    2. Add frozen vegetables on top.
    3. Dissolve a chicken broth cube hot or boiling water, pour into dish, add water to a bit above the rice.
    4. Place frozen chicken legs on top, or whatever other frozen chicken pieces you’d like.
    5. Generously season chicken.
    6. Stick in oven for about an hour at 200°C.

    You might need to add boiling water while it’s cooking, but after making it a couple times you’ll know about how much water is needed from the start.


  • Great intentions, but I’m a bit worried about how the non-contact breath detection will work, if you’re sober and giving your wasted friend(s) a ride home from the bar. BAC detection by touch might be better, if they can make it work that is.

    Seeing how cars with Super-cruise have eye tracking, why not roll impaired & distracted driving into one safety package.

    Eye tracking has become a reliable neuroscience tool for identifying the eye movements that are linked to impairments caused by alcohol use disorders. For example, a machine-learning model has been developed to detect alcohol intoxication based on a person’s eye gaze and eye closure. (From Google’s generated cliff notes)

    Disabling a vehicle if the driver isn’t looking at the road for x seconds might be a bit drastic. I could imagine e.g. muting the volume if not at the very least glancing at the road every 2~3 seconds. Would piss off a lot of people, then not long thereafter teach them to pay attention to where they are going.








  • Do not store your dirty underwear hermetically sealed! Stick it in a mesh or paper bag, something it can release the pent up humidity through; or you’ll get some really nasty laundry.

    For Pokemon trainers, I’m no expert, but wouldn’t they just stick their clean clothes in one poke’ball & dirty laundry in another?



  • DEA Hartford Task force and state police detectives received a tip that suggested Soule was operating a clandestine psilocybin mushroom growing operation at a home on Lyon Road.

    Fuck people who snitch on a grow-house, especially when it’s mushrooms which neither stink or bother anyone.

    Soule admitted to investigators that the mushrooms were in fact psilocybin, which is labeled as a “schedule 1″ controlled substance. State police said a schedule 1 controlled substance is defined as drugs, substances and chemicals that are not currently accepted for medical use and have a high potential for abuse.

    But more than anything, fuck the fucked up legacy of fucking Nixon. The only reason there isn’t accepted medical use, is because the government and DEA made it really hard for researchers to be allowed to use shrooms (& weed) in research. It’s ridiculous that especially shrooms are in the same ‘dangerous, addictive and no mental health benefits’ category as heroin.