Not really. Just as killing a person doesn’t kill an ideology, killing a person also doesn’t kill the profit motives for cartels.

If anything it makes the problem worse. Because you’ve suddenly freed up territory in a very lucrative black market.

The solution to the drug problem is to instead kill the motivations people have for doing the drugs in the first place:

https://www.psychiatrictimes.com/view/what-does-rat-park-teach-us-about-addiction

This means fixing the housing crisis, guaranteeing people jobs, food, water, shelter, and medical support. It means embracing harm reduction policy. It means ending the war on drugs.

Drug use is a symptom of an unhealthy society. Fix the health of society and the symptoms will disappear, and with it the cartels as well.